the shepherd lab

Success is not final, failure is not fatal: 
it is the courage to continue that counts.
                   - Sir Winston Churchill

our publications

  • Jessica G. Tong, Milani Sivapragasam, Yudith Ramos Valdes, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia, Trevor G. Shepherd (2017)  Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential. BMC Cancer 17: 594. [Pubmed]
  • Anna L. Greenshields, Trevor G. Shepherd and David W. Hoskin (2017) Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate. Mol Carcinog 56(1):75-93. [Pubmed]
  • Marta Llauradó Fernández, Gabriel E DiMattia, Amy Dawson, Sylvia Bamford, Shawn Anderson, Bryan T Hennessy, Michael S Anglesio, Trevor G Shepherd, Clara Salamanca, Josh Hoenisch, Anna Tinker, David G Huntsman, Mark S Carey (2016) Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines. American Journal of Cancer Research 6(10):2235-2251. [Pubmed]
  • James B. Greenaway, Carl Virtanen, Kata Osz, Tamas Revay, Daniel Hardy, Gabriel E. DiMattia, Trevor G. Shepherd, Jim Petrik (2016) Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer. Oncotarget 7(30):47343-47365 [Pubmed]
  • Daniel J. Klionsky, Kotb Abdelmohsen…Trevor G. Shepherd…Susu M. Zughaier (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12: 1-222. [Pubmed]
  • Samah Rafehi, Yudith Ramos Valdes, Jessica Tong, Monique Bertrand, Jacob McGee, Michel Préfontaine, Akira Sugimoto, Gabriel E. DiMattia, Trevor G. Shepherd (2016) Transforming growth factor-beta signalling regulates epithelial-mesenchymal transition in ascites-derived epithelial ovarian cancer spheroids. Endocrine-related Cancer 23: 147-59. [Pubmed]
  • Rohann J.M. Correa, Yudith R. Valdes, Trevor G. Shepherd and Gabriel E. DiMattia (2015) Beclin-1 expression is retained in high-grade serous ovarian cancer yet is not essential for autophagy induction in vitro. Journal of Ovarian Research 8:52. [Pubmed]
  • Jessica G. Tong, Yudith R. Valdes, John W. Barrett, John C. Bell, David Stojdl, Grant McFadden, J. Andrea McCart, Gabriel E. DiMattia, Trevor G. Shepherd (2015) Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis. Molecular Therapy Oncolytics 2: 15013 [Pubmed]
  • Teresa M. Peart, Yudith R. Valdes, Rohann J.M. Correa, Elena Fazio, Monique Bertrand, Jacob McGee, Michel Prefontaine, Akira Sugimoto, Gabriel E. DiMattia, Trevor G. Shepherd (2015) Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids. Oncotarget 6: 22424-38. [Pubmed]
  • Rohann J.M. Correa, Yudith R. Valdes, Teresa M. Peart, Monique Bertrand, Jacob McGee, Michel Prefontaine, Akira Sugimoto, Gabriel E. DiMattia, and Trevor G. Shepherd (2014) Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability. Carcinogenesis 35:1951-61. [Pubmed]
  • Mateusz Rytelewski, Jessica Tong, Adrian Buensuceso, Hon S. Leong, Saman Maleki Vareki, Rene Figueredo, Christine Di Cresce, Shelly M. Herbrich, Keith A. Baggerly, Larissa Romanow, Trevor G. Shepherd, Bonnie J. Deroo, Anil K. Sood, Ann Chambers, Mark Vincent, Peter J. Ferguson, James Koropatnick (2014) BRCA2 mediates cisplatin resistance by regulating tumor proliferation, metabolic response and metastatic frequency. Mol Oncol 8: 1429-40. [Pubmed]
  • Biljana Todorovic, Anthony C. Nichols, Jennifer M. Chitilian, Michael P. Myers, Trevor G. Shepherd, Sarah J. Parsons, John W. Barrett, Lawrence Banks, Joe S. Mymryk (2014) The human papillomavirus E7 proteins associate with and alter p190RhoGAP function. J Virol 88: 3653-63. [Pubmed]
  • Meaghan A. Melling, Charlotte Friendship, Trevor G. Shepherd, Thomas A. Drysdale (2013) Expression of ski can act as a negative feedback mechanism on retinoic acid signaling. Dev Dynamics 202: 604-613. [Pubmed]
  • Shoudong Li, Jessica Tong, Masmudur M. Rahman, Trevor G. Shepherd, Grant McFadden (2012) Oncolytic virotherapy of ovarian cancer. Oncolytic Virotherapy 1:1-21. [Pubmed]
  • Rohann J. M. Correa, Monica Komar, Jessica Tong, Milani Sivapragasam, Masmudur M. Rahman, Grant McFadden, Gabriel E. DiMattia, Trevor G. Shepherd (2012) Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity. Gynecol Oncol 125: 441-450. [Pubmed]
  • Teresa M. Peart, Rohann J.M. Correa, Yudith R. Valdes, Gabriel E. DiMattia and Trevor G. Shepherd (2012) BMP signalling controls the malignant potential of ascites-derived human epithelial ovarian cancer spheroids via AKT kinase activation. Clin Exp Metastasis 29: 293-313. [Pubmed]
  • Rohann J.M. Correa, Teresa M. Peart, Yudith R. Valdes, Gabriel E. DiMattia and Trevor G. Shepherd (2011) Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids. Carcinogenesis 33: 49-58. [Pubmed]
  • from previous work:
  • Brigitte L. Theriault & Trevor G. Shepherd (2011) On the Path to Translation: Highlights from the 2010 Canadian Conference on Ovarian Cancer Research. Journal of Ovarian Research 4: 10. [Pubmed]
  • Trevor G. Shepherd, Michelle L. Mujoomdar and Mark W. Nachtigal. (2010) Constitutive activation of BMP signalling abrogates experimental metastasis of OVCA429 cells via reduced cell adhesion. Journal of Ovarian Research 3: 5. [Pubmed]
  • Natasza A. Kurpios, Lesley MacNeil, Trevor G. Shepherd, David G. Gludish, Andrew O. Giacomelli and John A. Hassell (2009) The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. Developmental Biology 325:106-21. [Pubmed]
  • Trevor G. Shepherd, Brigitte L. Theriault and Mark W. Nachtigal (2008) Autocrine BMP4 signalling regulates ID3 proto-oncogene expression in human ovarian cancer cells. Gene 414: 95-105. [Pubmed]
  • Brigitte L. Theriault, Trevor G. Shepherd, Michelle L. Mujoomdar and Mark W. Nachtigal (2007) BMP4 signalling induces EMT and promotes the aggressive phenotype of human ovarian cancer cells. Carcinogenesis 28: 1153-62. [Pubmed]
  • Trevor G. Shepherd, Brigitte L. Theriault, Elizabeth Campbell & Mark W. Nachtigal (2006) Primary culture of ovarian surface epithelial cells and ascites-derived ovarian cancer cells from patients. Nat Protocols 1: 2643-9. [Pubmed]
  • Yangxin Fu, Laura M. O’Connor, Trevor G. Shepherd, Mark W. Nachtigal (2003) The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor ß (TGFß) induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun, 310: 391-7. [Pubmed]
  • Trevor G. Shepherd and Mark W. Nachtigal (2003) Identification of a putative autocrine bone morphogenetic protein (BMP) signaling pathway in human ovarian surface epithelium (OSE) and ovarian cancer (OC) cells. Endocrinology 144: 3306-14. [Pubmed]
  • Yangxin Fu, Elizabeth J. Campbell Dwyer, Trevor G. Shepherd and Mark W. Nachtigal (2003) Promoter hypermethylation and histone deacetylation contribute to reduced PACE4 gene expression in human ovarian cancer cells. Molec Cancer Res 1: 569-76. [Pubmed]
  • Natasza A. Kurpios, Nancy Sabolic, Trevor G. Shepherd, Gina Fidalgo and John A. Hassell (2003) Function of PEA3 ets transcription factors in mammary gland development and oncogenesis. J Mammary Gland Biol Neoplasia. 8: 177-90. [Pubmed]
  • Lesley D. Dunfield, Trevor G. Shepherd and Mark W. Nachtigal (2002) Primary culture and mRNA analysis of human ovarian cells. Biol Proced Online 4: 55-61. [Pubmed]
  • Trevor G. Shepherd, Lisa Kockeritz, Michelle R. Szrajber, William J. Muller and John A. Hassell (2001) The pea3 subfamily ets genes are required for HER2/Neu-mediated mammary oncogenesis. Curr Biol 11: 1739-1748. [Pubmed]
  • Trevor Shepherd and John A. Hassell (2001) Role of Ets transcription factors in mammary gland development and oncogenesis. J Mam Gland Biol Neoplasia 6: 129-140. [Pubmed]

  • Nelson K. S. Khoo, John F. Bechberger, Trevor Shepherd, Shari L. Bond, Keith R. McCrae, G. Scot Hamilton, and Peeyush K. Lala (1998) SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype. I. Mechanisms responsible for hyperinvasiveness and resistance to anti-invasive action of TGFbeta. Int J Cancer 77: 429-39. [Pubmed]