the shepherd lab

Far and away the best prize that life 
has to offer is the chance to work hard 
at work worth doing.
                   - Theodore Roosevelt

our research

Spheroid culture model of ovarian cancer metastasis: Spheroids are entities present in the malignant ascites fluid of ovarian cancer patients with late-stage disease; they afford the cells with increased viability, protection from chemotherapeutic insult, and increased capacity to re-attach and grow as secondary tumours in the peritoneal cavity. We routinely perform experiments in which ovarian cancer cells are cultured in suspension, where cells aggregate to form multicellular clusters called spheroids. The overall focus of our research efforts is to decipher the altered signalling pathways and pathophysiological processes that exist in ovarian cancer spheroids to identify new therapeutic vulnerabilities for metastatic disease and to overcome chemo-resistance.